Abstract: Our analyses demonstrated that some mutations may be associated with the outcome of
HAM/TSP (
C39R,
L40F,
P45L,
S69G and
R88K) or with proviral load (
P34L and
F61L).
Abstract: We further examined the presence of mutations in motifs of
HBZ and observed that
P45L mutation is located within the
HBZ nuclear localization signal and was found more frequently between patients with
HAM/TSP and high proviral load.