Analyses of HTLV-1 sequences suggest interaction between ORF-I mutations and HAM/TSP outcome.
PMID: 27553711
2016
Infection, genetics and evolution
Abstract: Our analyses demonstrated that some mutations may be associated with the outcome of HAM/TSP (C39R, L40F, P45L, S69G and R88K) or with proviral load (P34L and F61L).
Method: We selected the most frequent natural mutations within ORF-I sequences (F3L, S23P, D26N, G29S, P34L, C39R, L40F, P45L, F61L,