Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.
Abstract: A single amino acid (aa) substitution (S35L) was exclusive for the HC group, and three gp46 substitutions (F14S, N42H, G72S) were exclusive for the HAM/TSP group.
Abstract: The in silico protein analysis revealed that the mutated alleles F14S and N42H represent more hydrophilic and flexible protein domains that are likely to be less antigenic.
Result: Among the five mutations found, three (F14S, S35L and N42H) were not present in any of the 42 Brazilian sequences used to create the consensus.
HTLV1 mutation literature information.
PMID: 
2018
Virology journal
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