Abstract: A single amino acid (aa) substitution (S35L) was exclusive for the HC group, and three gp46 substitutions (F14S, N42H, G72S) were exclusive for the HAM/TSP group.

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Result: After submission of wild type and mutated sequences to SWISS-MODEL server, the results showed that the S35L and G72S mutations were associated to the change of coil for extended beta at the secondary structure prediction (Figure 5).

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Result: Among these common mutations, one (S35L) was exclusive to the HC group, three (F14S, N42H, G72S) wer

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