Low Proviral Load is Associated with Indeterminate Western Blot Patterns in Human T-Cell Lymphotropic Virus Type 1 Infected Individuals: Could Punctual Mutations be Related?
Result: The frequency of the TRE-1 G232A mutation (66.7%) in HIV/HTLV-1-coinfected patients was high as much as 61.8% reported by Neto's in HTLV-1 asymptomatic carriers with a high PvL.
Result: The frequency of the substitution A G in the second nucleotide (A domain) of the TRE-1 motif (the TRE-1 G232A mutation) and the substitution G A in the third nucleotide (A domain) of the TRE-2 motif (the TRE-2 Result: Thus, all the 13 subjects with the TRE-2 A184G mutation had the TRE-1 G232A mutation together.
Result: We also found that the frequency of double mutations of the TRE-1 G232A and the TRE-2 A184G in HIV/HTLV-1-coinfected was high (54.2%).
Correlation between LTR point mutations and proviral load levels among human T cell lymphotropic virus type 1 (HTLV-1) asymptomatic carriers.
Abstract: RESULTS: Using a categorical analysis, a G232A substitution, located in domain A of the TRE-1 motif, was detected in 38.7% (12/31), 27.5% (8/29), and 61.8% (21/34) of subjects with low, intermediate, or high PvLs, respectively.
Discussion: The G232A mutation is located in domain A of the TRE-1
Discussion: Therefore, additional experimental supports are needed to rule out the potential importance of the A184G mutations and functional connection between A184G and G232A mutations.
Discussion: Therefore, longitudinal study designs are required to address these issues and also to determine if the G232A mutations was already present in patients with advanced disease before they were diagnosed a chronic infection.
HTLV1 mutation literature information.
PMID: 
2015
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