Stability of the HTLV-1 glycoprotein 46 (gp46) gene in an endemic region of the Brazilian Amazon and the presence of a significant mutation (N93D) in symptomatic patients.
Discussion: (2013) recorded the S72G, N42H and F14S mutations in patients with HAM/TSP.
Discussion: In the present study, 21 of the samples presented amino acid mutations, of which, S35 L, F14S, and S72G have been described previously, and most are associated with specific functional domains.
Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals.
Abstract: A single amino acid (aa) substitution (S35L) was exclusive for the HC group, and three gp46 substitutions (F14S, N42H, G72S) were exclusive for the HAM/TSP group.
Abstract: The in silico protein analysis revealed that the mutated alleles F14S and N42H represent more hydrophilic and flexible protein domains that are likely to be less antigenic.
Result: Among the five mutations found, three (F14S, S35L and N42H) were not present in any of the 42 Brazilian sequences used to create the consensus.
HTLV1 mutation literature information.
PMID: 
2018
Virology journal
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