Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization.
Abstract: Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin.
Abstract: We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism.
Introduction: Further, a large body of experimental research on the differential biological activities of HPV16 variants has focused on the E6 gene, especially on the T350G polymorphism, corresponding to the L83V amino acid substitution in the E6 oncoprotein.
Introduction: However, the T350G polym
Identification and validation of immunogenic potential of India specific HPV-16 variant constructs: In-silico &in-vivo insight to vaccine development.
Discussion: It has been reported from various studies that gene variant T350G of HPV-16 was found to display more efficient degradation of Bax and strong binding to E6 binding protein.
Discussion: It is also showed that the variation T350G in HPV-16 E6 gene imparted an approximately 2 fold higher risk of viral persistence than prototype.
Variants of human papillomavirus type 16 predispose toward persistent infection.
PMID: 26339417
2015
International journal of clinical and experimental pathology
Abstract: It was found that the variants T178G, T350G and A442C in the E6 gene, as well as C3158A and G3248A variants in the E2 gene were associated with persistent HPV16 infection.
The human papillomavirus 16 European-T350G E6 variant can immortalize but not transform keratinocytes in the absence of E7.
Abstract: Of focus in this study is the European-T350G variant, which is characterized by an L>V amino acid substitution at residue 83 of the prototype E6 protein.
Abstract: To elucidate the functional effects of this polymorphism, we followed keratinocytes transduced with E-T350G E6 for over 60 passages and compared them to keratinocytes transduced, in parallel, with prototype or Asian-American (Q14H/L83V/H78Y) E6.
Abstract: We also found that E-T350G down-regulated E-cadherin compared to the other variants, providing a possible link between its population-based oncogenicity and host genetic variations.
Abstract: We found that although E-T350G
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Introduction: T350G causes a leucine to valine change (L83V), that leads to the split of the EUR sublineage into three classes, 350 T (prototype sequence), 350C and 350G.
Introduction: Several reports have shown the presence of common polymorphisms that generate amino acid changes in the E6 oncoprotein, one of them is T350G, and is present in the four lineages.
Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.
PMID: 25735347
2015
Asian Pacific journal of cancer prevention
Abstract: In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection.
High-sensitivity human papilloma virus genotyping reveals near universal positivity in anal squamous cell carcinoma: different implications for vaccine prevention and prognosis.
PMID: 25702585
2015
European journal of cancer (Oxford, England
Abstract: HPV 16 accounted for 89%; of these, 64% harboured the T350G E6 variant.
HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants.
Abstract: The results revealed that the European T350G was the most common variant (50%) followed by the European prototype (40.3%) and the North-American (N = 3; 4.8%).
Abstract: while the European T350G variants were seen in women with co-infections.
Human papillomavirus type 16 long control region and E6 variants stratified by cervical disease stage.
PMID: 24823962
2014
Infection, genetics and evolution
Abstract: Monitoring intra-lineage, site-specific variants, such as T350G, is unlikely to be of diagnostic value.
Abstract: None of these sites, however, including the T350G non-synonymous (L83V) substitution in E6, alone or in combination, were found to be associated with cervical disease stage.
Introduction: The HPV16 AA lineage variant and the EUR T350G (L83V) variant exhibit an increased propensity to transform primary human foreskin keratinocytes or induce apoptosis in organotypic raft cultures in vitro compared to the HPV16 prototype.
Introduction: Within the EUR variant lineage, a T350G substitution in the E6 gene leads to an altered amino
HPV mutation literature information.
PMID: 
2016
Journal of medical virology
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