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 HPV mutation literature information.


  Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India.
 PMID: 18199779       2008       Journal of clinical microbiology
Abstract: The most frequently observed variations were T350G (100%) in E6, T789C (87.5%) in E7, A6695C (54.5%) in L1, and G7521A (91.1%) in the LCR.


  Human papillomavirus typing of invasive cervical cancers in Italy.
 PMID: 17192187       2006       Infectious agents and cancer
Abstract: Of the 32 HPV 16 positive cases, sequencing of the E6 gene could be performed in 25; the prototype isolate was identified in 7, and the variant T350G in 18; in 4 cases one or more additional mutations were present.
Result: Interestingly, the A257G mutation has been firstly described very recently, and occurred in combination with the T350G variant, as in our case.
Result: Of the naturally occurring HPV 16 viral variants, the T350G (L83V) is the most commonly found among invasive cancers, and has been linked to an increased risk for cervical disease progression.


  Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer.
 PMID: 16786144       2006       Oncology reports
Abstract: Sequencing of the entire E6 and E7 genes of HPV16 showed a T to G transition at nucleotide position 350 of E6, in all examined cases.


  Human papillomavirus type 16 E6 and E7 genotypes in head-and-neck carcinomas.
 PMID: 15006625       2004       Oral oncology
Abstract: Sequence analysis of the E6-E7 segments revealed three different HPV16 E6-E7 genotypes: the HPV16 prototype (6 of 21 cases), the E6 variant T350G (8 of 21 cases), and the E6-E7 variant A131G/C712A (7 of 21 cases).
Abstract: The E6 variants T350G and A131G have been associated with increased oncogenic potential in cervical cancer patients depending on host genetic factors.


  [Causal association between human papilloma virus infection and head and neck and esophageal squamous cell carcinoma].
 PMID: 12050680       2002       Magyar onkologia
Abstract: HPV16E6 T350G mutant were observed only in two of eight carcinomas.


  Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix.
 PMID: 11308254       2001       British journal of cancer
Abstract: Isolates were also analysed for the HPV 16 350T-G variant.
Abstract: No relationship was found between the E6 350T-G variant, or the E2 hinge region 3410C-T variant, and lesion grade.


  Analysis of human papillomavirus type 16 E6 variants in relation to p53 codon 72 polymorphism genotypes in cervical carcinogenesis.
 PMID: 10644829       2000       The Journal of general virology
Abstract: An initial sequence analysis of HPV-16 long control, E6 and E7 regions of 53 well-defined cervical samples containing HPV-16 revealed that a T to G transition at nucleotide position 350 within the E6 open reading frame was the most common variation, the frequency of which seemed to decrease with increasing severity of the lesion.


  Rapid test for identification of a human papillomavirus 16 E6 L83V variant.
 PMID: 10475384       1999       Diagnostic molecular pathology
Abstract: This HPV 16 variant possesses a common mutation (T to G) in nucleotide 350 (codon 83) of the E6 gene, resulting in an amino acid shift, L83V, in the E6 protein.


  Human papillomavirus type 16 E6 variants in cervical carcinoma: relationship to host genetic factors and clinical parameters.
 PMID: 10567656       1999       The Journal of general virology
Abstract: The most common variation detected was a T to G transition at base pair 350, resulting in an amino acid change from a leucine to a valine.



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