Abstract: Based on the HPV16 prototype, the most frequent variation in the E6 gene was T178A/G (48.7%), followed by mutations of G94A (12.2%) and T350G (9.9%).
Result: Among the populations infected by the HPV16 E variant of T350G, 16 women (9.5%, 16/168, 95% CI 14.8-29.9) were persistent infections and 12 women (11.3%, 12/106, 95% CI 15.5-36.5) were transient infections.
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, <
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Abstract: At the amino acid level, the most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (G132T), and were observed respectively in 65%, 41.8%, 38.8%, 30.1% and 23.3% of total samples.Moreover, HPV16 European variants were mostly identified in younger women at early clinical diagnosis stages.
Result: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women.
PMID: 23946477
2013
Journal of medical microbiology
Abstract: Novel sequence variations were recorded within the E6 and E7 genes in cervical samples, characterized as (T350G) European variants.
Codon 72 polymorphism of p53 and HPV type 16 E6 variants as risk factors for patients with squamous epithelial lesion of the uterine cervix.
Abstract: In addition, T350G HPV 16 variant was over-represented in p53 Arg homozygous women with cervical lesions.
Abstract: The T350G HPV 16 variant was the most frequent variant observed in the analyzed group of Italian women, showing a slight decreasing with the severity of the lesion.
Abstract: When p53 genotype and HPV 16 variants are considered together, no difference emerges between cases and controls so is not possible to assess that the oncogenic effect of HPV 16 T350G variant may be influenced by the p53 genotype.
Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
Discussion: In either case, the consistent presence of change 350 T>G in the E1-1374 63nt E-G350 variant is unlikely to be able to significantly decrease the association with HSIL of this variant or increase it with LSIL.
Discussion: Of all changes from the reference found in the HPV16 E1-1374 63nt variant, the 350 T>G change has been reported most often.
Discussion: Some studies linked 350 T>G to higher oncogenic potential or viral persistence, but others did not.
Discussion: This was most evident for the frequently studied 350 T>G variation, since the E1-1374 63nt duplication is exclusively linked w
Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.
Introduction: The most frequent of these mutations is the T to G transition at nt 350 in E6, abbreviated as E-T350G, causing an amino acid change from leucine to valanine at a.a.
Result: The E-T350G variant was the most common one among all the three groups of samples.
Prevalence of HPV 16 genomic variant carrying a 63 bp duplicated sequence within the E1 gene in Slovenian women.
PMID: 22131113
2011
Acta dermatovenerologica Alpina, Pannonica, et Adriatica
Abstract: Recently, a novel, presumably less pathogenic, HPV-16 E6-T350G genomic variant has been identified, carrying a 63-bp in-frame insertion in the E1 gene.
[Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing].
Abstract: Our results suggested that the mutations of G7521A, A7729C, G7839A, T178G, T350G, A647G, and G658A were likely to be associated with the enhanced oncogenic potential of HPV16 and oncogenesis of cer-vical cancer.
Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosi City, Mexico.
Abstract: CONCLUSION: We conclude that in the women included in this study the HPV16 E subtype is 19 times more frequent than the AA subtype; that the circulating E variants are E-P (71.1%) > E-T350G (18.4%) > E-C188G (5.3%); that 71.0% of the E-P sequences carry the A334G single nucleotide change and appear to correspond to a HPV16 variant characteristic of San Luis Potosi City more oncogenic than the E-P Ref prototype.
Abstract: RESULTS: Three European (E) variants (E-P, n = 27; E-T350G, n = 7; E-C188G, n = 2) and one AA-a variant (n = 2) were identified among the 38 HPV16 sequences analyzed.
Result: Although the HSIL + ICC fraction was even higher for the AA-a, E-
Distribution of HPV-16 intratypic variants among women with cervical intraepithelial neoplasia and invasive cervical cancer in Mongolia.
PMID: 19256739
2008
Asian Pacific journal of cancer prevention
Abstract: Among the remaining 31 variants, variants with the T350G nucleotide change were predominant (13/31, 42%), followed by variants containing G94A (11/31, 35%), G176A (4/31, 13%) and G274T (2/31, 7%).
HPV mutation literature information.
PMID: 
2013
BMC cancer
Browser Board
Co-occurred Entities
Filtrator
ViMRT