Abstract: Among 110 mutations, 65 cases of E6 genes were mutated at nucleotide 350 (T350G) with the leucine changing to valine (L83V).
Introduction: T350G is the most common polymorphic mutation in European strains, which causes leucine to change to proline (L83V).
Discussion: Our study found seven HPV16 E6 T295G and T350G nucleotide co-mutations, which may serve as a variant of the HPV16 European mutant strain.
Discussion: Studies have shown that HPV16 E6-T350G mutations in Moroccan women are prevalent in high-grade cervical lesions and are closely related to the progress
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Result: The co-existence of LCR:C7577T, E5:A3979C, A4042G and E6:T350G variants were found in 10 A1 haplotypes or nodes (E-16, E-18, E-19, E-22, E-26, E-28, E-37, E-38, E-41 and E-42), majority of which were case specific or overrepresented among case samples and across all D haplotypes that represented cases only, except for specimen number T173, which lacked the T350G variant.
Result: Those, proportionately higher among tumor specimens were E5 (A3979C:Y44L, A4042G:I65V), E6 (
AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
PMID: 34512928
2021
Computational and structural biotechnology journal
Result: Among them, 8 specific mutations were missense mutation, including 83L>V (T350G) on the E6 gene, 219P>S (C3409T) on the E2 gene, 39I>L (A3977C) and 60I>V (A4040G) on the E5 gene, 43E>D (A4363T) and 330L>F (A5224C) on the L2 gene, 228H>D (C6240G) and 292 T>A (A6432G) on the
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Discussion: T350G (L90V) has been shown to be associated with the progression of cervical lesions.
Discussion: In our study, we did not find that HPV16 E6 T350G (L90V) was associated with cervical cancer risk, which is in good agreement with previous data in China.
Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population.
PMID: 32308546
2020
International journal of medical sciences
Introduction: For example, the T variation of the E6 gene T350G (L83V) persisted more often than the G variation in the EUR sub-lineage.
Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
PMID: 31933750
2019
International journal of clinical and experimental pathology
Abstract: In addition, the A4 sublineage T178G (P<0.001) and the A1/A2 sublineages T350G and A442C (P<0.001) were associated with persistent HPV16 infection.
Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.
PMID: 30578936
2019
Infection, genetics and evolution
Abstract: The most common SNP was the T350G (29/39 samples, 74.4%), causing the L83 V amino acid change in the E6.
Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.
Abstract: Results: Fourteen missense mutations were found in the E6 gene; the loci with the highest mutation frequency were T350G (36/75, 48%) and T178G (19/75, 25.3%).
Result: Nineteen single nucleotide changes were identified among the sequencing results for E6 and E7, including 14 missense mutations and five synonymous mutations: 11/14 missense mutations were distributed in the E6 gene (C168G, G176A, T178G, T178A, T183G, A275G, A276G, T295G, T350G, PMID: 31552532
2019
Archives of virology
Abstract: Moreover, the most frequent mutations, both in samples from this study and in the available sequences from Mexican isolates in the GenBank database were LCR-G7518A, which is involved in carcinogenesis, and E6-T350G (producing L83V), associated with persistence of infection.
HPV16 E6 mutations and p53 codon72 polymorphism among women with cervical intraepithelial neoplasia 2 and 3 in China.
PMID: 29787003
2016
European journal of gynaecological oncology
Abstract: RESULTS: Among the 85 amplified HPV sequences, point mutations such as T178G, T350G, G132A, A442C, T310G, G94T, C551A, etc.
HPV mutation literature information.
PMID: 
2022
Cancer cell international
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