HPV mutation literature information.


  Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.
 PMID: 34847982       2021       Expert reviews in molecular medicine
Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.


  Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
 PMID: 22574185       2012       PloS one
Discussion: For example, E2 T310K has been linked to high grade histology in cervical carcinoma.



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