Result: All African lines showed a common pattern of five characteristic mutations in E6, namely, C143G, G145T, T286A, A289G, and C335T, which lead to two non-synonymous amino acid changes Q14D and H78Y.
Result: The most frequently observed variations were C143G (Q14D), G145T (Q14D), T286A, A289G and C335T (H78Y), which was found in all samples.
Discussion: At the E6 genomic region, five cha
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T, T350G, A442C lead to amino acid changes (I52V, H78Y, L83V, E113D, respectively), while C256T, T286A, A289G are silent not leading to amino acid changes.
Result: The E6 pattern corresponded to the prototype in 7 c
HPV mutation literature information.
PMID: 
2015
Infectious agents and cancer
Browser Board
Co-occurred Entities
Filtrator
ViMRT