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 HPV mutation literature information.


  Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.
 PMID: 20870281       2010       Gynecologic oncology
Abstract: CONCLUSIONS: These findings suggest that C632T (T20I) and G760A (G63S) variants in HPV58 E7 are probably risk factors associated with the development of cervical cancer in Chinese women.
Abstract: For HPV58, the presence of C632T (T20I) and G760A (G63S) variants in E7 showed a positive trend of the association with the severity of neoplasia (P(trend)<0.05, chi2 test for trend).


  Association of human papillomavirus type 58 variant with the risk of cervical cancer.
 PMID: 12189229       2002       Journal of the National Cancer Institute
Abstract: Among HPV58-positive women, the occurrence of E7 632C-->T (T20I) and E7 
Abstract: Patients with CIN III or ICC who were also infected with T20I/G63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P =.038, two-sided Mann-Whitney U test).
Abstract: Thus, HPV58 variants carrying E7 T20I/G63S substitutions may be associated with an increased risk for cervical cancer.



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