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 HPV mutation literature information.


  Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.
 PMID: 33155930       2021       Anti-cancer agents in medicinal chemistry
Abstract: CONCLUSION: The HPV58 E7 T20I variant did not promote malignant behaviors compared with wild-type HPV58 E7.
Abstract: However, the HPV58 E7 T20I variant did not promote malignant behaviors compared with wildtype HPV58 E7.
Abstract: OBJECTIVE: This study aimed to determine whether the HPV58 E7 T20I (C632T) variant promotes the malignant behavior of cervical cancer cells and the underlying mechanism of the HR-HPV E7 oncoprotein involved in the development of cervical cancer.


  Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.
 PMID: 31996427       2020       Journal of virology
Abstract: Our previous international epidemiological studies revealed that HPV58 carrying an E7 natural variant, T20I/G63S (designated V1), was associated with a higher risk of cervical cancer.
Abstract: Since V1 is more commonly found in eastern Asia, our report provides insight into the design of HPV screening assays and selection of components for HPV vaccines in this region.IMPORTANCE Epidemiological studies have revealed that a wild-type variant of HPV58 carrying an E7 variation, T20I/G63S (V1), is associated with a higher risk of cervical cancer.


  Genetic variability and oncogenic risk association of human papillomavirus type 58 E6 and E7 genes in Taizhou area, China.
 PMID: 30471332       2019       Gene
Abstract: The sublineage A3 variants with T20I/G63S substitutions at E7 oncoprotein carried a significantly higher risk for high-grade cervical intraepithelial neoplasia (CIN2 or worse, CIN2+) when compared with other HPV58 variants (odds ratio = 4.41, P < 0.05).


  Oncogenic comparison of human papillomavirus type 58 E7 variants.
 PMID: 30575267       2019       Journal of cellular and molecular medicine
Discussion: Interestingly, our previous epidemiological results fo
Discussion: Moreover, we have focused on E7 variations in this study, as our previous studies showed that sequence variations of HPV58 mainly reside in E7, while E6 is relatively conserved among individuals.27 Given that both E6 and E7 are major HPV oncoproteins, it is anticipated that co-expression of E6 prototype with the E7 variants could give a more complete picture of HPV oncogenesis and might reveal more additional oncogenic properties that contribute to the increased cervical cancer risk of the E7 V1 (T20I/G63S) variant.


  The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China.
 PMID: 29695285       2018       Virology journal
Abstract: Six non-synonymous amino acid substitutions (including S71F and K93 N in the E6, and
Result: In the E7, 6 SNPs were detected (6/297, 2.0% nucleotide variation), of which T744G was identified in 64% variants (7/11), and 5 SNPs resulted in amino acid changes including T20I, G41R, G63S, G63D and V77A.
Result: In the HPV-58 E7, the non-synonymous substitution T20I was affecting the MHC class-I binding peptide HPEPTDLFC (E7 16-24) and the MHC class-II binding peptide LHPEPTDL (E7 15-22).


  E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
 PMID: 28141822       2017       PloS one
Result: The positively selected sites for HPV-33 E6 were K35N, K93N, and R145I; for HPV-33 E7 were S29T, A45V, A45E, and Q97L; for HPV-58 E6 were K93N, R145K; and for HPV-58 E7 were T20I, G41R, G63S, and G63D.
Discussion: In the present study, G542T (R145I, a positive mutation) in HPV-33 E6 and


  Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.
 PMID: 28794033       2017       Journal of virology
Result: For example, the A3 sublineage-specific nucleotide variations of E7 C632T (amino acid T20I); E1 C1965T; E2 A3685G; NCR2 A4192C; L2 G4570A, A4609G, and A4935C (N231T); L2/L1 A5579C (L2 M446L or L1 L5F); L1 


  Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women.
 PMID: 29945151       2017       Intervirology
Abstract: For E7, 17 known mutations were found, the most frequent were C632T (T20I), 35.30%, G760A (G63S), 35.30%, and t744g 74.50%.


  Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
 PMID: 23136059       2013       International journal of cancer
Discussion: Amino acid substitution(s) T20I and/or G63S at E7 is(are) associated with a higher risk for CIN3 and invasive cervical cancer.
Discussion: Isolates carrying G63S and/or T20I were found to have an independent increase in risk for CIN3 and invasive cervical cancer.
Discussion: Only one variant harbored G63S alone without T20I.


  Human papillomavirus type 58: the unique role in cervical cancers in East Asia.
 PMID: 22571619       2012       Cell & bioscience
Abstract: An HPV58 variant (E7 T20I, G63S) commonly detected in Hong Kong was found to confer a 6.9-fold higher risk of developing cervic
Introduction: The first amino acid substitution (T20I) is close to the Leu-Xaa-Cys-Xaa-Glu domain that mediates association with the retinoblastoma protein (pRb) and its related proteins, p107 and p130.
Introduction: This variant harboring two amino acid substitutions, T20I and G63S, in the E7 protein was found to associate with an odds ratio of 10.14 (95% confidence interval = 10.14-74.72) for the development of cervical cancer, which was 6.9-fold higher than HPV58 variants without these sequence variations.



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