Result: Another nucleotide substitution was also found in nucleotide site 178, T178A (D32E), with the same amino acid change as T178G but belonging to the A3 (European) sublineage.
Result: Moreover, our data showed that the oncogenicity of HPV16 E6 T178G (D32E) and E7 A647G (N29S) variation was associated with an increased risk of CIN2+ (OR = 2.24 ~ 2.45) (Table 2).
Result: The three most prevalent nucleotide substitutions were T178G (D32E) (191/298, 64.1%) in the E6 gene and PMID: 30930693
2019
Cancer cell international
Abstract: Results: Fourteen missense mutations were found in the E6 gene; the loci with the highest mutation frequency were T350G (36/75, 48%) and T178G (19/75, 25.3%).
Discussion: T178G (D25E) variations are mainly distributed in the Asian population (such as China, Japan and South Korea); the mutation can interact with Human Lymphocyte Antigen (HLA) gene polymorphisms and promote the development of cervical cancer.
Discussion: In this study, a total of 13 polymorphic sites were identified in 75 HPV16 E6 sequences, and T350G (36/75, 48%) and T178G (19/75, 25.3%) comprised the majority of 11 missense mutations, this result is consistent with that of Cai
Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
PMID: 31933750
2019
International journal of clinical and experimental pathology
Abstract: CONCLUSION: HPV16 E6 variants in the Shanghai Pudong District mainly belong to the A4 sublineage, and detection of the specific HPV E6 T178G genotype may be considered a risk factor for viral persistence and progression to other cervical diseases.
Abstract: In addition, the A4 sublineage T178G (P<0.001) and the A1/A2 sublineages T350G and A442C (P<0.001) were associated with persistent HPV16 infection.
HPV16 E6 mutations and p53 codon72 polymorphism among women with cervical intraepithelial neoplasia 2 and 3 in China.
PMID: 29787003
2016
European journal of gynaecological oncology
Abstract: RESULTS: Among the 85 amplified HPV sequences, point mutations such as T178G, T350G, G132A,
Abstract: The rate of HPV16 E6 mutation T178G in CIN2, 3 group was significantly higher than that in normal and CINI group, i.e., in the 112 amplified p53 codon72 sequences, the distribution of Pro/Pro genotype in normal, and CIN1 group was significantly different from that in CIN2, 3 groups, and the disease risk of Pro/Pro genotype was much higher than that of Arg/Arg and Arg/Pro genotypes.
Abstract: were found, among which, T178G showed the highest rate (51.76%).
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Introduction: Other polymorphisms including A131G, G132C, C143G, G145T, G176A, T178G and C335T generate the amino acid changes R10G/I, Q14H/D, D25E/N, I27R and H78Y, respectively.
Variants of human papillomavirus type 16 predispose toward persistent infection.
PMID: 26339417
2015
International journal of clinical and experimental pathology
Abstract: It was found that the variants T178G, T350G and A442C in the E6 gene, as well as C3158A and G3248A variants in the E2 gene were associated with persistent HPV16 infection.
Intratypic variants of human papillomavirus type 16 and risk of cervical neoplasia in Taiwan.
Abstract: Similar significant associations with cervical intraepithelial neoplasia grade 3 or worse were also observed for distinct nucleotide substitutions, including T178A/G, A647G, A7730C/G, T7781C, G7842A, and C24T/G.
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
Abstract: Based on the HPV16 prototype, the most frequent variation in the E6 gene was T178A/G (48.7%), followed by mutations of G94A (12.2%) and T350G (9.9%).
Result: Several variations in E6 and LCR were co-segregated, including T178G in E6 gene and T7201C, C7270T, A7287C, A7289C,
Result: The most frequent nucleotide variation was T178G/A (49.7%, 151 of 304), in which T178G was found in 113 strains and T178A in 38 strains (Table 2).
Research on sequence variations analysis of HPV-16 type in Southwestern China.
PMID: 24601042
2013
European journal of gynaecological oncology
Abstract: RESULTS: Compared with the European-Germanyl31 (EG131), 20 mutations were detected, of which eight mutations were detected from all the four biopsies: 131(G-A)(Gly-Arg), 178 (T-G)(Asp-Glu),350 (G-T)(Val-Leu), 647 (A-G)(Asn-Asp),846 (T-C) (synonymous mutation), L1 966th (C-T)(synonymous mutation),L1 1302 (C-T)(synonymous mutation) and L1 1434th (A-G) (synonymous mutation).
HPV mutation literature information.
PMID: 
2022
Cancer cell international
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