Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.
Abstract: For HPV16, The most prevalent mutations were T266A (27/27) and N181T (7/27) for L1, D32E for E6 and S63F for E7 in HPV16.
Result: The most frequently observed non-synonymous in HPV16 E7 genes were C7791T (S63F) (Table 5).
Discussion: It was reported that the S63F mutation was more frequent in women with carcinoma cancer.
Discussion: The reason was assumed that the S63F variation had an influence on the E7 epitopes and caused viral persistence and PMID: 34847982
2021
Expert reviews in molecular medicine
Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.
Human papillomavirus type 16 E6 and E7 gene variations associated with cervical cancer in a Han Chinese population.
PMID: 30981880
2019
Infection, genetics and evolution
Abstract: However, the distribution of C749T (S63F) in the E7 gene was significantly different between the case and control groups for the A4 (As) and A1-A3 (EUR) sub-lineages (P = 1.815 x 10-8 and P = 0.008).
Abstract: In the current study, we found that the C749T (S63F) variation in the HPV16 E7 gene was associated with cervical cancer not only in the A4 (As) sub-lineage but also in the A1-A3 (EUR) sub-lineage.
Abstract: When the distribution of the HPV16 E6 and E7 gene variations was compared, the distribution of only A131C (R10R) in the E6 gene s
Codon Usage Optimization and Construction of Plasmid Encoding Iranian Human Papillomavirus Type 16 E7 Oncogene for Lactococcus Lactis Subsp. Cremoris MG1363
PMID: 28441787
2017
Asian Pacific journal of cancer prevention
Result: These variations induce the amino acid changes N29S, and S63F, respectively.
Discussion: Also, the amino acid substitutions S63F (57.66 %), and R66W (72.39 %) were positioned at the C-terminal domain of the E7 oncoprotein due to the nucleotide changes C188T, and R196W respectively.
Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China.
PMID: 16603519
2006
The Journal of general virology
Abstract: The results also showed that the prevalences of three hot spots of E7 nucleotide variation, N29S, S63F and a silent variation, nt T846C, were 70.2 % (33/47), 51.1 % (24/47) and 61.7 % (29/47), respectively.
HPV mutation literature information.
PMID: 
2022
Virology journal
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