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 HPV mutation literature information.


  CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.
 PMID: 34544280       2021       mBio
Abstract: E2-S23A (E2 with serine 23 mutated to alanine) activates and represses transcription identically to E2-WT (wild-type E2), and E2-S23A is as efficient as E2-WT in transient replication assays.
Abstract: However, E2-S23A has compromised interaction with mitotic chromatin compared with E2-WT.
Abstract: In E2-S23A cells, neither E2 nor TopBP1 levels increase during mitosis.



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