Result: The highest efficiency in overcoming the G1 block was exhibited by the E6 variants R10G (r = 0.9) and R48W (r = 0.8), while R8Q showed the lowest efficiency (r = 1.4) (Figure 2C).
Discussion: R10G and R48W induced hyperplastic proliferation similar to that induced by the high prevalence type L83V, whereas the R8Q cultures had a unique phenotype, characterized by lack of stratification.
Discussion: Previous studies with site directed mutants demonstrated that other amino acid c
Discussion: The rare variant R8Q exhibited significantly higher ability to augment Wnt/TCF-beta-catenin transcription, an activity that could be of advantage in keratinocyte transformation.
Activities of human papillomavirus 16 E6 natural variants in human keratinocytes.
HPV mutation literature information.
PMID: 
2011
Molecular cancer
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