Result: Injection of DNA plasmids encoding LucE6(R55K)(delK75)/E7(R53S), NRasG12V, and SB100 followed by EP results in development of sarcoma in the oral/pharyngeal cavity in HLA-A2 (AAD) transgenic mice.

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Result: Then, DNA plasmids encoding LucE6(R55K)(delK75)/E7(R53S), NRasG12V, and SB100 were injected into the submucosa of the oral/pharyngeal cavity of mice followed by EP.

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Figure: Histological examination of tumors formed in HLA-A2 (AAD) transgenic mice injected with plasmids encoding LucE6(R55K)(delK75)/E7(R53S), NRasG12V, and Sleeping Beauty transposase (SB100) followed by electroporation.

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