Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.
Abstract: Besides the selection of some common variants in both BC and CACX, some unique variants in BC (D98Y; 395 G>T) and CACX (R48W; 245 G>T) were observed.
Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential.
Result: The highest efficiency in overcoming the G1 block was exhibited by the E6 variants R10G (r = 0.9) and R48W (r = 0.8), while R8Q showed the lowest efficiency (r = 1.4) (Figure 2C).
Discussion: R10G and R48W induced hyperplastic proliferation similar to that induced by the high prevalence type L83V, whereas the R8Q cultures had a unique phenotype, characterized by lack of stratification.
Discussion: NIKS
Discussion: The largest increase was in R48W and was statistically significant when compared to the vector cells.
Discussion: This was more pronounced in the L83V and the R48W cultures.
HPV mutation literature information.
PMID: 
2018
Virus research
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