Discussion: Our previous study reported another within-host E1 variant, Q381E, which was present at a relatively high abundance (5.42%) in one ICC sample.
Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.
Abstract: In transient replication assays, a novel E1 mutant found in ICC, E1 Q381E, showed reduced ability to support HPV16 origin-dependent replication.
Result: Further, nucleotide variation analyses showed a novel aa variation at position 381 from glutamine (prototype) to glutamic acid (Q381E) in sample 6.
Result: In contrast, Q381E exhibited a reduced activity for supporting HPV16 replication, and Y379F completely lost the replication activity as expected.
Result: Intriguingly, the nucleotide substitutions observed in the E1 gene of sample 6 cause amino-acid (aa) changes in the E1 protein: methionine at aa
HPV mutation literature information.
PMID: 
2020
Frontiers in microbiology
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