literature

HPV mutation literature information.

The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer.

PMID: 20383192 2010 Oncogene

Abstract: The different prevalence is based on three amino acid changes within the E6 protein denoted Q14H/H78Y/L83V.

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.

PMID: 18986660 2009 Virology

Abstract: In addition, E6 variant NIKS expressing R10G/L83V and Q14H/H78Y/L83V were more prone to undergo cell-detachment-induced apoptosis (anoikis) than NIKS expressing E6 prototype.

Discussion: Nevertheless both Q14H/H78Y/L83V and Discussion: Our data may explain the high prevalence of certain HPV16 E6 variants in populations and in high-grade cervical disease worldwide, especially with respect to the Asian-American variant Q14H/H78Y/L83V.

Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosi City, Mexico.

PMID: 19216802 2009 Infectious agents and cancer

Result: The expected amino acid changes were also found in AA-a (Q14H; H78Y; L83V) and E-C188G variants (E20Q; L83V).

Molecular variants of HPV-16 associated with cervical cancer in Indian population.

PMID: 19358280 2009 International journal of cancer

Abstract: The most frequent being L83V (72.3%), Q14H (13.1%) and H78Y (12.1%).

Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers.

PMID: 17311337 2007 Journal of medical virology

Abstract: At the amino acid level, the isolates showed 14 variants including E6 Q14H, E6 D25E, E6 I27R, E6 H78Y, E6 L83V, and E7 N29S.

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