Result: Then, DNA plasmids encoding LucE7(N53S)E6(R55K)(delK75), AKT, c-Myc, and SB100 were injected into the submucosa of the oral/pharyngeal cavity of mice, followed by EP.
Result: These cell lines were further transfected with CRT/E7 or CRT/E7(N53S) DNA constructs.
Result: These data indicated transfection of cells with DNA encoding CRT linked to E7(N53S) abolishes the pres
Figure: One day later, the mice were injected with plasmids pKT2-LucE7(N53S)E6(R55K)(delK75), pKT2-CLP-AKT, pKT2-cMyc, and pCMV-SB100 via submucosal injection in the oral/pharyngeal cavity followed by electroporation (EP).
Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escape.
PMID: 17962940
2008
Cancer immunology, immunotherapy
Abstract: We have found immunoresistance of the clones to correlate with the point mutation in the E7 oncogene, which resulted in the N53S substitution in the immunodominant epitope RAHYNIVTF (aa 49-57).
HPV mutation literature information.
PMID: 
2022
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