Result: However, the common non-synonymous mutation A to G transition at nt 647 and causing amino acid change N29S, was found in 3 (23.0%) out of 13 sequences.
Table: N29S
Discussion: However, E7 protein with the N29S mutation present an identical power transforming has the prototype strain, after measuring the cooperation E7/activated ras gene in rat embryo fibroblast cells.
Discussion: In addition, N29S is involved in binding to pRB and could alter the affinity of the E7 protein for pRB, or modification of the oncogenic potential.
Discussion: The two others were non-synonymous mutations, of which a common described N29S was found in three isolates (23%).
Prevalence of HPV and variation of HPV 16/HPV 18 E6/E7 genes in cervical cancer in women in South West China.
Abstract: There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S.
Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
Discussion: It is of interest that the only candidate site which was positively selected N29S is located within the domains which are important for the transforming activity of this protein and these domains are know to be involved in binding retinoblastoma suppressor protein (pRB).
Whole genome analysis of human papillomavirus type 16 multiple infection in cervical cancer patients.
PMID: 22524831
2012
Asian Pacific journal of cancer prevention
Abstract: An amino acid variation N29S within the E7 oncoprotein significantly associated with severity of lesion was also discovered.
Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.
PMID: 21593270
2011
Journal of clinical microbiology
Abstract: The most prevalent amino acid variations were D25E in E6 and N29S in E7.
Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.
PMID: 21436703
2011
International journal of gynecological cancer
Abstract: The results also showed the prevalence of 4 hot spots of E7 nucleotide variations leading to N29H, N29S, and 2 silent variations, nucleotide G666A and nucleotide T846C, with 4.2% (6/142), 43% (61/142), 32.4% (46/142), and 43% (61/142), respectively.
[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].
PMID: 20104743
2009
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: There were two nucleotide mutation at E6 position 178 (T-->G,D25E) and at E7 position 647 (A-->G, N29S) in 4 Asian type like viruses.
[Association between human papillomavirus (HPV) type 16 infection and E6/E7 gene variant and the cervical lesions in Beijing].
PMID: 17429529
2007
Zhonghua shi yan he lin chuang bing du xue za zhi
Abstract: D32E/N29S mutation rate was 38.9% (28/72), the detection rate increased with the severity of cervical lesions (P < 0.05).
Abstract: A mutation, E6-D32E (T96G) coincided with a specific type of E7 mutation, N29S (A86G).
Abstract: CONCLUSION: HPV 16 was the most common type in women with cervical lesions in Beijing, D32E/N29S variant associated with the cervical lesions.
HPV mutation literature information.
PMID: 
2016
Gynecologic and obstetric investigation
Browser Board
Co-occurred Entities
Filtrator
ViMRT