literature

HPV mutation literature information.

Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.

PMID: 34847982 2021 Expert reviews in molecular medicine

Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.

Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.

PMID: 34217247 2021 BMC cancer

Result: Moreover, our data showed that the oncogenicity of HPV16 E6 T178G (D32E) and E7 A647G (N29S) variation was associated with an increased risk of CIN2+ (OR = 2.24 ~ 2.45) (Table 2).

Result: The three most prevalent nucleotide substitutions were T178G (D32E) (191/298, 64.1%) in the E6 gene and A647G (N29S) (195/298, 65.4%) and T846C (192/298, 64.4%) in the E7 gene, which are specific to the A4 (Asian) sublineage.

Table: N2

Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants.

PMID: 33573298 2021 International journal of molecular sciences

Conclusion: Our findings show, for the first time, that an amino acid change in a variant (N29S and H51N) affected the 3D structure of the E7

Conclusion: The mutation of asparagine 29 to serine in the N29S variant was reported to confer an additional phosphorylation site at S29 due to its proximity to the CKII recognition motif, which phosphorylates S31 and S32.

Conclusion: The stability we observed in the MD simulation trajectories of N29S could be induced by this additional phosphorylation, which affected the global structure of the protein.

A Phase II, Prospective, Randomized, Multicenter, Open-Label Study of GX-188E, an HPV DNA Vaccine, in Patients with Cervical Intraepithelial Neoplasia 3.

PMID: 31727676 2020 Clinical cancer research

Abstract: The HPV sequence analysis revealed that the HPV type 16 E6/E7 variants D25E, V83L, and N29S were inversely associated with histopathologic regression at V8.

Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.

PMID: 31670402 2020 Journal of medical virology

Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have

Abstract: The H85Y and E120D variants in E6 were significantly reduced in the high-grade squamous intraepithelial lesion (HSIL) group compared to the <HSIL group (P = .046 and .005), conversely the N29S in E7(P = .01).

Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai.

PMID: 31832087 2019 Infectious agents and cancer

Abstract: However, T7220G (D32E) variation in HPV16 E6 and A7689G (N29S) in HPV16 E7 increased the incidence of HSIL compared to the <HSIL group (P = 0.036 and 0.022).

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.

PMID: 30930693 2019 Cancer cell international

Result: These caused the amino acid to change from threonine to serine (T22S), aspartic acid to asparagine (D25N), aspartic acid to glutamic acid (D25E), aspartic acid to glutamine (D25Q), isoleucine to arginine (I27R), asparagine to aspartic acid (N58D), asparagine to serine (N58S), aspartic acid to glutamic acid (D64E), leucine to valine (L83V), threonine to lysine (T86K), glutamic acid to aspartic acid (E113D), leucine to phenylalanine (L28F), asparagine to histidine (N29H) and asparagine to serine (N29S), respectively.

Identification of the impact on T- and B- cell epitopes of human papillomavirus type-16 E6 and E7 variant in Southwest China.

PMID: 27693214 2017 Immunology letters

Abstract: For the B-cell epitopes, three most potent epitopes for E6 were listed, and N29S lead the growth of score from 0.81 to 0.83.

Abstract: The mutations of D25E and L83V of E6 and N29S of E7 produce new epitopes, and the percentile values change with them.

A naturally occurring variant of HPV-16 E7 exerts increased transforming activity through acquisition of an additional phospho-acceptor site.

PMID: 27829177 2017 Virology

Abstract: A common E7 variant encodes an amino acid change at N29S.

Abstract: Biologically, these biochemical differences are reflected in an increased ability of the N29S variant to transform primary rodent cells.

Abstract: This is the first study to demonstrate an important biochemical change in E7 function caused by a naturally occurring variation, and we suggest that the N29S variant merits further assessment to determine whether it has an increased association with the development of HPV-associated malignancies.

Codon Usage Optimization and Construction of Plasmid Encoding Iranian Human Papillomavirus Type 16 E7 Oncogene for Lactococcus Lactis Subsp. Cremoris MG1363

PMID: 28441787 2017 Asian Pacific journal of cancer prevention

Result: These variations induce the amino acid changes N29S, and S63F, respectively.

Discussion: Boumba et al., (2015) explained two common silent variations and described mutations N29S among isolates from Asia, and Africa (23%).

Discussion: Our results explain the amino acid substitutions N29S (10.42 %) was located at the N-terminal domain of the E7 oncoprotein because of the nucleotide changes A86G.

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