Introduction: For example, L83V (L90V) of HPV-16 E6 in Swedish and Italian populations as well as D25E (D32E) of HPV-16 E6 in Japanese populations have been proven to be associated with the progression of cervical cancer.
Result: In HPV-16 E6, I34R, L35V, R62I, P66A and L90V all located in beta-fold, E120D, D32N, D32E located in the periphery of the spatial protein structure and close to the active region of znic granules.|mg
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Discussion: T350G (L90V) has been shown to be associated with the progression of cervical lesions.
Discussion: In our study, we did not find that HPV16 E6 T350G (L90V) was associated with cervical cancer risk, which is in good agreement with previous data in China.
HPV mutation literature information.
PMID: 
2022
Virology journal
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