Human papillomavirus type 16 E6 variants and HLA class II alleles among Japanese women with cervical cancer.
PMID: 12918070
2003
International journal of cancer
Abstract: Additionally, DRB1*1502 was positively associated with a particular E6 variant designated D25E (n = 25), although we could not find a significant association between HLA class II alleles and L83V variants (n = 16).
Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women.
Abstract: Women with HLA-B*44, HLA-B*51, or HLA-B*57 who were infected with the HPV16 E6 variant L83V had an approximately four- to fivefold increased risk for cancer compared with controls (odds ratio [OR] = 3.5, 95% CI = 1.1-11.1, OR = 4.2, 95% CI = 1.19-14.69, or OR = 4.67, 95% CI = 1.2-18.6, respectively).
[Causal association between human papilloma virus infection and head and neck and esophageal squamous cell carcinoma].
Abstract: DNA was extracted from 150 fresh or paraffin embedded biopsy specimens, and analyzed for HPV by PCR with 15 sets of consensus primers directed to conserved regions of L1 gene, three sets of HPV16E6 primers (specific for the HPV 16 prototype and L83V variant), and sets of primers specific for the E6 gene of other mucosa type HPVs including HPV 6, 11, 16, 18, 52, 58, 66 and 73.
Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease.
Abstract: In addition, we found a specific European E6 variant, L83V, to be enriched in high-grade lesions and cancer rather than a specific European long control region variant.
Introduction: This E6 variant showed an amino acid change from leucine to valine at residue 83 (L83V).
Result: E6-L83V, on the other hand, has previously been shown to be associated with high-grade lesions and cancer in Swedish women and Norwegian
Result: A statistically significant trend for an increased prevalence of E6-L83V with increasing severity of the lesion (P=0.04) was observed, while this was not the case for LCR-7193/7521 (P=0.15) (Table 2).
Human papillomavirus 16 E6 polymorphisms in cervical lesions from different European populations and their correlation with human leukocyte antigen class II haplotypes.
PMID: 11745467
2001
International journal of cancer
Abstract: For instance, the HPV16-E6 L83V variant, which has been found to be positively associated with ICC in Swedish women (p = 0.002), was more prevalent in LCIN than in ICC in Italian and Czech women (p = 0.01 and = 0.03, respectively).
Abstract: Indeed, the DR04-DQ03 haplotype, which is approximately 3-fold more abundant in the normal Swedish population than in those in Italy and the Czech Republic, was found to be positively associated with HPV16-E6 L83V in the 3 cohorts investigated (p = 0.01).
Abstract: These data indicate that host genetic factors, such as HLA polymorphism, may determine the potential oncogenicity of the HPV16-E6<
HPV-16 E6 L83V variant in squamous cell carcinomas of the upper aerodigestive tract.
Abstract: Most of the malignant HPV16 variants contain a common mutation, L83V, in the E6 oncoprotein.
Abstract: Prototype HPV16 and its E6 variant L83V are both prevalent in preinvasive and invasive cervical lesions in Swedish women.
Abstract: The HPV16 E6 variant L83V was present in 40% of the HCIN lesions, in 54% of the invasive adenocarcinomas, in comparison to 81% of the invasive squamous carcinomas.
Abstract: These HPV16-positive cases were evaluated with analysis of the E6 gene, using a recently described PC
Absence of antibody against human papillomavirus type 16 E6 and E7 in patients with cervical cancer is independent of sequence variations.
PMID: 10783118
2000
The Journal of infectious diseases
Abstract: All E6 antigens (the prototype and the variants 350G?L83V, 131G?R10G/350G?L83V, 335T?H78Y/350G?L83V, 345G?Y81C/350G?L83V, and African 2 ?Af2) showed cross-reactivity by RIPA.
Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer.
PMID: 10389753
1999
International journal of cancer
Abstract: Of all variants identified, the E6 variant 350G (L83V) and the E7 variant 822G were most frequently detected irrespective of histology and showed prevalence rates of 27% to 43% and 7% to 20%, respectively.
HPV-16 E6 L83V variant in squamous cell carcinomas of the upper aerodigestive tract.
Abstract: A DNA sequence analysis of the PCR products revealed the conversion of Leu to Val in codon 83 of the E6 gene, correlating to the divergent band pattern.
Abstract: The purpose of the present investigation is to describe a rapid method for the detection of this variant HPV 16, E6 (L83V).
Abstract: This HPV 16 variant possesses a common mutation (T to G) in nucleotide 350 (codon 83) of the E6 gene, resulting in an amino acid shift, L83V, in the E6 protein.
HPV mutation literature information.
PMID: 
2003
International journal of cancer
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