Abstract: RESULTS: The rare E6 variant R10G was relatively frequent (19%) in TSCC, absent in CC and infrequent (4%) in CS, while the well-known L83V variant was common in TSCC (40%), CC (31%), and CS (29%).
Introduction: Several studies on the L83V variant have demonstrated an association with viral persistence and cancer progression of cervical carcinoma, although some later studies have failed to confirm this association.
Result: Among these 53 samples 17% (9/53) carried the R10G and 34% (18/53) the
Whole genome analysis of human papillomavirus type 16 multiple infection in cervical cancer patients.
PMID: 22524831
2012
Asian Pacific journal of cancer prevention
Abstract: HPV16 European variant prone to single infection may harbor a major variation at L83V which significantly increases the risk for developing cervical carcinoma.
Abstract: In the E6 region, amino acid changes at L83V were related to increased cancer progression.
Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.
Result: Additionally, HPV-16 E6 L83V is associated with an increased risk of persistent infection and cytological progression to CIN types 2 and 3 and to squamous cell carcinoma in European populations.
Result: Furthermore, one HPV-16 E6 variant harboring an amino acid change at position 83 by substituting leucine for valine (L83V) was reported in Swedish and Italian populatio
Result: evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as well as for the prototype.
Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential.
Abstract: Like L83V, raft cultures derived from variants R10G and R48W similarly induced hyperplasia and aberrantly expressed keratin 5 in the suprabasal compartment with significantly lower expression of keratin 10.
Abstract: Unlike L83V, both variants, and particularly R48W, induced increased levels of anoikis upon suspension in semisolid medium.
Abstract: We evaluated functions relevant to carcinogenesis for the rarely-detected European variants R8Q, R10G and R48W as compared to the commonly detected L83V.
Introduction: In a previous study we investigated the functional characteristics of L83V-related E6
Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.
PMID: 21436703
2011
International journal of gynecological cancer
Abstract: Sequences of the E6 gene revealed 4 amino acid changes of variants D25E and L83V, with 48.3% (69/143) and 11.2% (16/143), respectively, and variants H78Y and E113D in this study.
The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer.
Abstract: The different prevalence is based on three amino acid changes within the E6 protein denoted Q14H/H78Y/L83V.
Human papillomavirus type 16 E6 gene variations in Chinese population.
PMID: 19699050
2010
European journal of surgical oncology
Abstract: The rank orders of incidence of HPV 16 prototype and E6 variants were as follows: D25E (62%), the prototype (17%), E113D (9%), L83V (6%) in case subjects; the prototype (71%), D25E (23%), L83V/E113D (7%) in control subjects.
Extensive anal condylomatosis: prognosis in relation to viral and host factors.
HPV mutation literature information.
PMID: 
2012
PloS one
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