Human papillomavirus type 16 long control region and E6 variants stratified by cervical disease stage.
PMID: 24823962
2014
Infection, genetics and evolution
Abstract: None of these sites, however, including the T350G non-synonymous (L83V) substitution in E6, alone or in combination, were found to be associated with cervical disease stage.
Introduction: The HPV16 AA lineage variant and the EUR T350G (L83V) variant exhibit an increased propensity to transform primary human foreskin keratinocytes or induce apoptosis in organotypic raft cultures in vitro compared to the HPV16 prototype.
Introduction: Within the EUR variant lineage, a T350G substitution in the E6 gene leads to an altered amino acid residue (L83V) and has been associated with HPV16 persistence and cervical
HPV16 E6 variants: frequency, association with HPV types and in silico analysis of the identified novel variants.
Abstract: Phylogenetic analysis revealed that the variant F69L + L83V is not related to any of these lineages, while the variant M137L + L83V is closely related to the North American variant.
Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
Result: Controlling for study site, age and smoking, detection of the variant R10G/L83V (OR 4.7, 95% CI 1.0-23.5; p=0.04) was significantly associate
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, T350G and A442C, which led to amino acid variations of R10G, D25E, H78Y, L83V and E113D, respectively.
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Abstract: At the amino acid level, the most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (G132T), and were observed respectively in 65%, 41.8%, 38.8%, 30.1% and 23.3% of total samples.Moreover, HPV16 European variants were mostly identified in younger women at early clinical diagnosis stages.
Discussion: Additionally, E6 variants R10G/L83V and Q14H/H78Y/
Molecular and evolutionary analysis of HPV16 E6 and E7 genes in Greek women.
PMID: 23946477
2013
Journal of medical microbiology
Abstract: Human papillomavirus type 16 (HPV16) non-European variants have been associated with persistent infection and cervical cancer development, while the L83V variant of the E6 gene has been correlated with the progression of cervical malignancy.
Abstract: Moreover, the prototype and E6 L83V variants were both prevalent in high- and low-grade malignancies in Greek women.
Abstract: The E6 L83V variant was found in 78.2 % of high- and 64.28 % of low-grade specimens.
Abstract: The present study investigated the presence of the HPV16 L83V variant in Greek wome
E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam.
Abstract: There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S.
Degradation of p53 by natural variants of the E6 protein of human papillomavirus type 16.
Abstract: These results suggest that the natural variants, E6 D25E and L83V, similar to the prototype E6 protein, contribute to tumorigenesis by degrading p53.
Abstract: Two variants of E6 proteins, D25E and L83V, are common in cervical carcinomas among Asian and European populations.
Abstract: Two variants of E6 proteins, D25E and L83V, are common in cervical carcinomas among Asian and European populations.
Abstract: We demonstrate that both the D25E and L83
Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
Discussion: A previous study found that L83V appears to enhance MAPK signaling and L83V is involved in oncogenic Ras-mediated transformation, efficient degradation of Bax and binding to E6BP and decreased binding to human discs large protein (hDlg).
Discussion: For example, the L83V polymorphism located within the epitope which binds to MHC molecules was found to be associated with cervical tumor development.
Discussion: In addition, this L83V polymorphism also appears to interact with natural human variations in the P53 genes (in particular codon 72 polymorphism) to confer differences in cervical cancer risk.
Discussion: Previous studies have found that mutations in the amino acid p
Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
HPV mutation literature information.
PMID: 
2014
Infection, genetics and evolution
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