literature

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.

PMID: 18986660 2009 Virology

Abstract: L83V-related variants of human papillomavirus (HPV) 16 E6, exemplified by the Asian-American variant Q14H/H78Y/L83V, were shown to be more prevalent than E6 prototype in progressing lesions and cervical cancer.

Abstract: In addition, E6 variant NIKS expressing R10G/L83V and Q14H/H78Y/L83V were more prone to undergo cell-detachment-induced apoptosis (anoikis) than NIKS expressing E6 prototype.

Abstract: The combined differentiation and apoptosis pattern of high-risk E6 L83V variant in squamous cell carcinomas of the upper aerodigestive tract.

PMID: 18841393 2009 Journal of cancer research and clinical oncology

Abstract: The HPV-16 E6 L83V variant was present in five cases.

Abstract: The potential prognostic significance of HPV-16 E6 L83V variant in HPV-16 positive UADT-SCCs should be more extensively investigated.

Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers.

PMID: 17311337 2007 Journal of medical virology

Abstract: At the amino acid level, the isolates showed 14 variants including E6 Q14H, E6 D25E, E6 I27R, E6 H78Y, E6 L83V, and E7 N29S.

Activities of human papillomavirus 16 E6 natural variants in human keratinocytes.

PMID: 17854024 2007 Journal of medical virology

Abstract: The I27R/L83V variant showed the lowest activity whereas the R8Q variant showed the highest activity.

Abstract: The L83V polymorphism previously associated with risk for cancer progression in some populations, showed significant activity, comparable to that of the E6 prototype, in reducing p53 and Bax levels.

Abstract: This, and augmentation of other described functions might result in differences in L83V pathogenicity.

Human papillomavirus typing of invasive cervical cancers in Italy.

PMID: 17192187 2006 Infectious agents and cancer

Result: Of the naturally occurring HPV 16 viral variants, the T350G (L83V) is the most commonly found among invasive cancers, and has been linked to an increased risk for cervical disease progression.

Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T, T350G, A442C lead to amino acid changes (I52V, H78Y, L83V,

PMID: 16603519 2006 The Journal of general virology

Abstract: In addition to D25E and E113D, the following E6 variations were found in this study: R129K, E89Q, S138C, H78Y, L83V and F69L.

HPV16 E6 natural variants exhibit different activities in functional assays relevant to the carcinogenic potential of E6.

PMID: 16519914 2006 Virology

Abstract: On the other hand, L83V displayed more efficient degradation of Bax and binding to E6BP, but lower binding to hDlg.

Abstract: The L83V polymorphism, previously associated with risk for cancer progression in some populations, expressed similar levels of activity as that of the E6 prototype in most functional assays.

[Investigation of human papillomavirus, its types and variants].

PMID: 16333213 2005 Medicina (Kaunas, Lithuania)

Abstract: HPV 16 (55.8% in squamous cell carcinoma patients and 35.3% in cervical adenocarcinoma patients) and its European HPV 16 L83V variant were detected more frequently in cervical cancer patients.

Interaction of host and viral risk factors for development of cervical carcinoma in situ.

PMID: 15929080 2005 International journal of cancer

Abstract: However, an association was found between the HPV 16 E6 L83V variant and the DR*04-DQ*03 haplotype.

[Analysis of human papillomavirus 16 E6 oncogene mutation in Xinjiang Uygur women with cervical carcinoma].

PMID: 15363193 2004 Ai zheng

Abstract: RESULTS: The result of PCR showed that the positive rate of HPV16E6 was 82.86%(29/35); 26 of these 29 PCR fragments were sequenced and analyzed, 15 of them maintained prototype (57.69%), 11 have L83V mutation (34.62%), and 2 have L83V/D63E mutation (7.69%).