Abstract: Moreover, the most frequent mutations, both in samples from this study and in the available sequences from Mexican isolates in the GenBank database were LCR-G7518A, which is involved in carcinogenesis, and E6-T350G (producing L83V), associated with persistence of infection.
High frequency of HPV16 European variant E350G among Mexican women from Sinaloa.
PMID: 30425223
2018
The Indian journal of medical research
Discussion: However, the E350G (or L83V) intra-variant primarily found in our study was not associated with the development of CC in all European populations.
Identification of the impact on T- and B- cell epitopes of human papillomavirus type-16 E6 and E7 variant in Southwest China.
Introduction: Further, a large body of experimental research on the differential biological activities of HPV16 variants has focused on the E6 gene, especially on the T350G polymorphism, corresponding to the L83V amino acid substitution in the E6 oncoprotein.
Discussion: To tackle this connection between viral genotypic diversity and cancer risk, a long-studied candidate has been the T350G(L83V) single-nucleotide polymorphism in the HPV16 genome 38, 39.
Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.
Discussion: Lineage B-specific mutations included the most frequently detected nonsynonymous mutation K93R (A379G) in E6, while lineage C-specific mutations included an E6 nonsynonymous mutation (L83V, concurrent mutations of C348G and G350T) and five E7 nonsynonymous mutations, S52D (concurrent mutations of A706G and G707A), Y55D (T727G), H61Y (C733T), D64N (G742A) and L99R
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Introduction: T350G causes a leucine to valine change (L83V), that leads to the split of the EUR sublineage into three classes, 350 T (prototype sequence), 350C and 350G.
Discussion: L83V amino acid change display more efficient degradation of Bax and binding to E6AP, induces ubiquitination and degradation of p53, NFX1-91 and PDZ proteins.
Discussion: According to the HPV variants found in this study, the amino acid substitutions circulating in Southern Mexico are: Q3E, R10G, Q14H, D25N, I27L, I27R I27T, L28V, E29K, E29Q, PMID: 25735347
2015
Asian Pacific journal of cancer prevention
Abstract: In the E6 sequences, the most common mutation was T350G (L83V), detected in 67% of the samples, associated with increased risk of persistent infection.
Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes.
PMID: 25800725
2015
Journal of virological methods
Abstract: Interestingly, the presence of variation H78Y and L83V result in creation of four new epitopes for the HLA-DQA1*0101/DQB1*0501.
The human papillomavirus 16 European-T350G E6 variant can immortalize but not transform keratinocytes in the absence of E7.
Abstract: To elucidate the functional effects of this polymorphism, we followed keratinocytes transduced with E-T350G E6 for over 60 passages and compared them to keratinocytes transduced, in parallel, with prototype or Asian-American (Q14H/L83V/H78Y) E6.
Distribution of human papillomavirus type 16 variants in Lithuanian women with cervical cancer.
Abstract: CONCLUSIONS: The European HPV 16 L83V variant is usually associated with high risk of cervical cancer among women.
Abstract: However, statistically significant difference was not achieved when comparing difference of L83V variants between investigated groups and in HPV 16 L83V variant and prototype distribution in CIN3/Ca in situ and cancer.
Abstract: In 33 cases (34.4%) HPV 16 prototype was detected; in 50 cases (52.1%), L83V variant; and in remaining 13 cases (13.5%), multivariant of HPV 16.
Abstract: The frequency of L83V variant in invasive cancer and carcinoma in situ samples was the same (66.7% and 62.0%, respectively; P=0.696).
HPV mutation literature information.
PMID: 
2019
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