Abstract: Among 110 mutations, 65 cases of E6 genes were mutated at nucleotide 350 (T350G) with the leucine changing to valine (L83V).
Introduction: T350G is the most common polymorphic mutation in European strains, which causes leucine to change to proline (L83V).
Discussion: There were 65 cases of E6 gene mutations at 350 nucleotides (T350G) with a mutation frequency of 63.64%, and corresponding amino acid change of leucine valine (L83V).
Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.
Abstract: The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/L83V), E-A176/G350 (D25N/L83V), E6-AAa (Q14H/H78Y/83V) y E6-AAc (Q14H/I27RH78Y/L83V) and E6-reference of HPV-16 with MAG
The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China.
Introduction: For example, L83V (L90V) of HPV-16 E6 in Swedish and Italian populations as well as D25E (D32E) of HPV-16 E6 in Japanese populations have been proven to be associated with the progression of cervical cancer.
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Abstract: Among the A1 viruses, an association of variants in the E5 (Y44L, I65V), E6 (L83V) genes and LCR: C7577T with SCC, with combined Odd's ratio (95% CI) of 20.5(4.61-91.25) was observed.
Result: Those, proportionately higher among tumor specimens were E5 (A3979C:Y44L, A4042G:I65V), E6 (T350G:L83V), and LCR (C7577T) with a combined o
AutoVEM2: A flexible automated tool to analyze candidate key mutations and epidemic trends for virus.
PMID: 34512928
2021
Computational and structural biotechnology journal
Result: Among them, 8 specific mutations were missense mutation, including 83L>V (T350G) on the E6 gene, 219P>S (C3409T) on the E2 gene, 39I>L (A3977C) and 60I>V (A4040G) on the E5 gene, 43E>D (A4363T) and 330L>F (A5224C) on the
Discussion: For HPV-16, the T350G (83L>V) mutation we detected is the most common mutation on the E6 gene of HPV-16.
Genetic analysis of human papilloma virus 16 E6/E7 variants obtained from cervical cancer cases in Chhattisgarh, a central state of India.
Abstract: L83V mutation was observed in 76.2% sequences followed by S71C seen in 28.6% sequences.
Abstract: Asian sequences showing higher frequency of L83V mutations and exclusive presence of S71C and C140 Stop codon mutations may be linked with higher oncogenicity.
Abstract: Other than L83V and S71C, E6 and E7 mutations were reported for the first time from India.
Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.
PMID: 34847982
2021
Expert reviews in molecular medicine
Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.
Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population.
PMID: 32308546
2020
International journal of medical sciences
Introduction: For example, the T variation of the E6 gene T350G (L83V) persisted more often than the G variation in the EUR sub-lineage.
Mutational landscape and intra-host diversity of human papillomavirus type 16 long control region and E6 variants in cervical samples.
Abstract: Moreover, the most frequent mutations, both in samples from this study and in the available sequences from Mexican isolates in the GenBank database were LCR-G7518A, which is involved in carcinogenesis, and E6-T350G (producing L83V), associated with persistence of infection.
Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.
PMID: 30578936
2019
Infection, genetics and evolution
Abstract: The most common SNP was the T350G (29/39 samples, 74.4%), causing the L83 V amino acid change in the E6.
HPV mutation literature information.
PMID: 
2022
Cancer cell international
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