Discussion: Positive selection sites K35N and K93N of HPV-33 E6
Discussion: The N86H, R145I of HPV-33 E6 and D86E, R145K of HPV-58 E6 occurred in the same positions; K93N of HPV-33 E6, K93R of HPV-52 E6 and K93N of HPV-58 E6 all located in the 93rd of the E6 protein; those amino acid substitutions located in protein active region, can cause the E6 terminal and the trend of the carboxyl end structure disorder.
Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai.
Abstract: Six non-synonymous amino acid substitutions (including S71F and K93 N in the E6, and T20I, G41R, G63S/D, and V77A in the E7) were affecting multiple putative epitopes for both CD4+ and CD8+ T-cells.
Result: C321T and A388C resulted in the amino acid changes including S71F and K93 N, respectively.
E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.
Abstract: K93N and R145 (I/N) were observed in both HPV-33 and HPV-58 E6.
Result: K93N and R145 (I/N) of HPV-33 and HPV-58 E6 were observed at the same two positions.
Result: The positively selected sites for HPV-33 E6 were K35N, K93N, and R145I; for HPV-33 E7 were S29T, A45V, A45E, and Q97L; for HPV-58 E6 were K93N, R145K; and for HPV-58 E7 were
HPV mutation literature information.
PMID: 
2022
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