Abstract: METHODS: We investigated the effects of UV induced DNA damage in murine models of beta-PV
E6 oncoprotein driven skin tumorigenesis by crossing K14-HPV8-E6wt mice (developing
skin tumors after UV treatment) with K14-CPD-photolyase animals and by generating the K14-HPV8-
E6-
K136N mutant mouse strain.
Abstract: Whereas all K14-HPV8-E6wt animals develop
skin tumors after UV expression of the HPV8-
E6-
K136N mutant significantly blocked
skin tumor development after UV treatment.
Method: Site-directed mutagenesis of HPV8-
E6 in K14CreERtam-HPV8-
E6 (also called K14-HPV8-
E6) a
HPV mutation literature information.
PMID: 
2015
Molecular cancer
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