Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes.
Abstract: Among the A1 viruses, an association of variants in the E5 (Y44L, I65V), E6 (L83V) genes and LCR: C7577T with SCC, with combined Odd's ratio (95% CI) of 20.5(4.61-91.25) was observed.
Result: Those, proportionately higher among tumor specimens were E5 (A3979C:Y44L, A4042G:I65V), E6 (T350G:L83V), and LCR (C7577T) with a combined o
Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.
PMID: 34847982
2021
Expert reviews in molecular medicine
Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.
Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
HPV mutation literature information.
PMID: 
2022
Translational oncology
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