Result: M1K made epitope affinity increase; R17G, D32N, D32E, I34R, L35V, P66A, H85Y and L90V changed epitope number and affinity; E120D and R151T made new epitopes appear.
Table: H85Y
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Result: However, both C335T (H85Y) and A646C (N29H) non-synonymous substitutions appeared in 7% (21/298) of HPV16 isolates at the same time in this TZHPV study.
Result: Notably, C335T (
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.
Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.
Abstract: The H85Y and E120D variants in E6 were si
HPV mutation literature information.
PMID: 
2022
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