literature

HPV mutation literature information.

Gene expression profiles are altered in human papillomavirus-16 E6 D25E-expressing cell lines.

PMID: 21943319 2011 Virology journal

Result: evaluated functions relevant to carcinogenesis for the E6 variants L83V, R10/L83V and Q14H/H78Y/L83V as well as for the prototype.

Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.

PMID: 21436703 2011 International journal of gynecological cancer

Abstract: Sequences of the E6 gene revealed 4 amino acid changes of variants D25E and L83V, with 48.3% (69/143) and 11.2% (16/143), respectively, and variants H78Y and E113D in this study.

The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer.

PMID: 20383192 2010 Oncogene

Abstract: The different prevalence is based on three amino acid changes within the E6 protein denoted Q14H/H78Y/L83V.

[Gene characterization of E6 and E7 gene of human papillomavirus of 15 cervical cancer in Beijing].

PMID: 20104743 2009 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: There were one nucleotide mutation at E6 position 335 (C-->T, H78Y) in 1 of 4 Europe prototype like virus.

Molecular variants of HPV-16 associated with cervical cancer in Indian population.

PMID: 19358280 2009 International journal of cancer

Abstract: The most frequent being L83V (72.3%), Q14H (13.1%) and H78Y (12.1%).

Human papillomavirus type 16 variants in cervical intraepithelial neoplasia and invasive carcinoma in San Luis Potosi City, Mexico.

PMID: 19216802 2009 Infectious agents and cancer

Result: The expected amino acid changes were also found in AA-a (Q14H; H78Y; L83V) and E-C188G variants (E20Q; L83V).

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis.

PMID: 18986660 2009 Virology

Result: The R10G/L83V culture exhibited the highest staining and compared to vector, prototype and Q14H/H78Y/L83V rafts the difference was statistically significant.

Discussion: Nevertheless both Q14H/H78Y/L83V and R10G/L83V demonstrated signific

Discussion: Our data may explain the high prevalence of certain HPV16 E6 variants in populations and in high-grade cervical disease worldwide, especially with respect to the Asian-American variant Q14H/H78Y/L83V.

Distinctive distribution of HPV16 E6 D25E and E7 N29S intratypic Asian variants in Korean commercial sex workers.

PMID: 17311337 2007 Journal of medical virology

Abstract: At the amino acid level, the isolates showed 14 variants including E6 Q14H, E6 D25E, E6 I27R, E6 H78Y, E6 L83V, and E7 N29S.

Human papillomavirus typing of invasive cervical cancers in Italy.

PMID: 17192187 2006 Infectious agents and cancer

Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T, T350G, A442C lead to amino acid changes (I52V, H78Y, L83V, E113D, respectively), while C256T, T286A, A289G are silent not leading to amino acid changes.

Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China.

PMID: 16603519 2006 The Journal of general virology

Abstract: In addition to D25E and E113D, the following E6 variations were found in this study: R129K, E89Q, S138C, H78Y, L83V and F69L.

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