Abstract: The aim of this work was to evaluate, with an in silico approach, employing molecular dynamics simulation and protein-protein docking, the interaction of the intragenic variants E-G350 (L83V), E-C188/G350 (E29Q/
Figure: (C) Visualization of amino acid changes: Q14H, D25N, I27R, H78Y and L83V are in licorice.
Figure: Zoom visualization of amino acid changes: Q14H, D25N, I27R, E29Q, H78Y and L83V.
Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.
PMID: 34847982
2021
Expert reviews in molecular medicine
Abstract: Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Epsilon7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised.
Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.
Abstract: Whereas, 145 G>T (Q14H) and 335 C>T (H78Y) variants of E6 showed association with either early invasiveness of BC and/or poor outcome of the patients.
Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates.
Abstract: The most frequently observed nucleotide variations were the missense C143G, G145T and C335T in E6 (100%), leading to the non-synonymous amino acid variation Q14D and H78Y.
Result: All African lines showed a common pattern of five characteristic mutations in E6, namely, C143G, G145T, T286A, A289G, and C335T, which lead to two non-synonymous amino acid changes Q14D and H78Y.
Result: The most frequently observed variations were
Table: H78Y
Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Discussion: Q14R/H78Y/L83V amino acid changes gender AA variants with increased oncogenic potential and more efficient evasion of the host's immune su
Discussion: The amino acid substitutions present in the HPV 16 E6 variants in descending order of association with CC were: Q14R/H78Y/L83V (AA-a variant), D25N/L83V (E-A176/G350 variant), Q14R/I27/H78Y/L83V (AA-c variant), L83V (E-G350 variant) and E29Q/L83V (E-C188/G350 variant).
Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes.
PMID: 25800725
2015
Journal of virological methods
Abstract: Interestingly, the presence of variation H78Y and L83V result in creation of four new epitopes for the HLA-DQA1*0101/DQB1*0501.
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
Abstract: The rank orders of incidence of E6 variations in amino acid were as follows: D25E (46.3%), L83V (9.9%) and H78Y (4.3%).
Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 mi
Result: The rank orders of E6 variants in amino acid were as follows: D25E (49.7%, 151/304), L83V (9.9%, 30/304), H78Y (4.3%, 13/304), R10G (3.0%, 9/304) and E113D (2.6%, 8/304).
Table: H78Y
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Abstract: At the amino acid level, the most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (G132T), and were observed respectively in 65%, 41.8%, 38.8%, 30.1% and 23.3% of total samples.Moreover, HPV16 European variants were mostly identified in younger women at early clinical diagnosis stages.
Result: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113
Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.
Introduction: In a previous study we investigated the functional characteristics of L83V-related
Discussion: High activity of the Asian American variant Q14H/H78Y/L83V in apoptosis induction was suggested to be related to its high persistence and increased risk of progression to cancer (reported to be 20-fold higher than that of prototype E6).
Discussion: In an earlier investigation NIKS transduced with the E6 variants Q14H/H78Y/L83V and R10G/L83V demonstrated significantly higher levels of late apoptotic cells when suspended in methylcellulose than L83V.
HPV mutation literature information.
PMID: 
2022
Scientific reports
Browser Board
Co-occurred Entities
Filtrator
ViMRT