Modeling and Molecular Dynamics of the 3D Structure of the HPV16 E7 Protein and Its Variants.
PMID: 33573298
2021
International journal of molecular sciences
Abstract: Epidemiological studies have proposed that the presence of the N29S and H51N variants of the HPV16 E7 protein is significantly associated with cervical cancer.
Conclusion: Interestingly, the N29S mutation confered greater 3D structure stability compared to those of the H51N variant and the E7 reference; this outcome may be related to
Conclusion: Our findings show, for the first time, that an amino acid change in a variant (N29S and H51N) affected the 3D structure of the E7 protein.
Conclusion: The H51N variant showed a lower 3D structure stability than the other systems.
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
HPV mutation literature information.
PMID: 
2021
International journal of molecular sciences
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