Discussion: The occurrence of C632T and G760A in the HPV-58 E7, which were identified in our study and resulted in the amino acid changes including T20I and G63S, respectively, has been implied to be linked to an increased risk for cervical cancer.
Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.
Abstract: For E7, 17 known mutations were found, the most frequent were C632T (T20I), 35.30%, G760A (G63S), 35.30%, and t744g 74.50%.
Genetic variability of HPV-58 E6 and E7 genes in Southwest China.
PMID: 24368255
2014
Infection, genetics and evolution
Abstract: 8 single nucleotide changes were identified among the HPV-58 E7 sequences with 2/8 synonymous mutations (T726C, T744G) and 6/8 non-synonymous mutations (G599A, C632T, G694A, G760A, G761A, T803C).
Abstract: The most common mutations of E7 genes are C632T, G694A, T744G, G760A (from Gly to Ser, in turn), G761A and T803C.
Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.
Abstract: CONCLUSIONS: These findings suggest that C632T (T20I) and G760A (G63S) variants in HPV58 E7 are probably risk factors associated with the development of cervical cancer in Chinese women.
Abstract: For HPV58, the presence of C632T (T20I) and G760A (G63S) variants in E7 showed a positive trend of the association with the severity of neoplasia (P(trend)<0.05, chi2 test for trend).
Association of human papillomavirus type 58 variant with the risk of cervical cancer.
PMID: 12189229
2002
Journal of the National Cancer Institute
Abstract: Among HPV58-positive women, the occurrence of E7 632C-->T (T20I) and E7 760G-->A (G63S) variants (T20I/G63S) showed a positive trend of association with the severity of neoplasia (P(trend)<.001, chi(2) test for trend).
HPV mutation literature information.
PMID: 
2018
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