Phylogenetic analysis of Human papillomavirus 16 variants isolated from Indian Breast cancer patients showed difference in genetic diversity with that of cervical cancer isolates.
Conclusion: G7193T and G7521A detected in all the infections, were predicted to locate at the binding site for FOXA1 and SOX9, respectively.
Result: The mutation frequency varied from 2% (1/48) to 100% (48/48), among which the G7193T
Table: G7521A
Discussion: In addition, the nucleotide changes G7193T and G7521A, which accounted for 100% of the infections in our study, were the most prevalent.
Discussion: The G7521A variant was located at the binding site of the transcriptional repressor SOX9, a potential tumor suppressor in cervical cancer, and suppressesing cervical tumor growth through transactivating p21WAF1/CIP1.
Association of human papillomavirus type 16 and its genetic variants with cervical lesion in Korea.
Abstract: The most commonly observed LCR variations were 7521G>A (91.5%), 7730A>C (59.6%), and 7842G>A (59.6%).
Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.
PMID: 25735347
2015
Asian Pacific journal of cancer prevention
Abstract: The most frequent mutation in LCR sequences was G7521A, in 80% of the analyzed samples; it affects the binding site of a transcription factor that could contribute to carcinogenesis.
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
Abstract: The most commonly observed LCR variations were the transition replacement G7193T, 7434CIns, G7521A and 7863ADel (100%).
Result: The most common LCR variations were G7193T, 7434CIns, G7521A, 7863ADel, which were found in 100% of HPV16 isolates.
Table: Discussion: Because of the strong cosegregation of the co-variations of G7193T, 7434CIns, C7436T, G7521A, and 7863Adel, it is impossible to determine if each variation in it was individually responsible for risk for developing CIN2,3.
Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.
PMID: 21593270
2011
Journal of clinical microbiology
Abstract: The most frequently observed variation sites were T178G (32.69%) in E6; A647G (34.62%), G666A (38.46%), and T846C (32.69%) in E7; C6826T (36.17%) and G7060A (61.70%) in L1; and G7521A (98.08%) in the LCR.
[Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing].
Abstract: A total of 8 hot mutation spot was identi-fied, which were URR G7521A (100%), C7435G (96.77%), C24T (45.16%), A7729C (45.16%), G7839A (45.16%), E6 T178G (41.94%), E7 A647G (45.16%), and T846C (45.16%).
Abstract: Our results suggested that the mutations of G7521A, A7729C, G7839A, T178G, T350G, A647G, and G658A were likely to be a
Human papillomavirus type 16 variant analysis of E6, E7, and L1 genes and long control region in biopsy samples from cervical cancer patients in north India.
PMID: 18199779
2008
Journal of clinical microbiology
Abstract: The most frequently observed variations were T350G (100%) in E6, T789C (87.5%) in E7, A6695C (54.5%) in L1, and G7521A (91.1%) in the LCR.
A non-radioactive PCR-SSCP analysis allows to distinguish between HPV 16 European and Asian-American variants in squamous cell carcinomas of the uterine cervix in Colombia.
HPV mutation literature information.
PMID: 
2018
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