Abstract: Among HPV58-positive women, the occurrence of
E7 632C-->T (
T20I) and
E7
Abstract: Patients with
CIN III or
ICC who were also infected with
T20I/
G63S variants had a statistically significant younger age at diagnosis than those infected with other variants (median age = 37 years versus 48 years; P =.038, two-sided Mann-Whitney U test).
Abstract: Thus, HPV58 variants carrying
E7 T20I/
G63S substitutions may be associated with an increased risk for
cervical cancer.
HPV mutation literature information.
PMID: 
2002
Journal of the National Cancer Institute
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