literature

HPV mutation literature information.

Human Papillomavirus 58 E7 T20I/G63S Variant Isolated from an East Asian Population Possesses High Oncogenicity.

PMID: 31996427 2020 Journal of virology

Abstract: Our previous international epidemiological studies revealed that HPV58 carrying an E7 natural variant, T20I/G63S (designated V1), was associated with a higher risk of cervical cancer.

Abstract: Since V1 is more commonly found in eastern Asia, our report provides insight into the design of HPV screening assays and selection of components for HPV vaccines in this region.IMPORTANCE Epidemiological studies have revealed that a wild-type variant of HPV58 carrying an E7 variation, T20I/G63S (V1), is associated with a higher risk of cervical cancer.

Genetic variability and oncogenic risk association of human papillomavirus type 58 E6 and E7 genes in Taizhou area, China.

PMID: 30471332 2019 Gene

Abstract: The sublineage A3 variants with T20I/G63S substitutions at E7 oncoprotein carried a significantly higher risk for high-grade cervical intraepithelial neoplasia (CIN2 or worse, CIN2+) when compared with other HPV58 variants (odds ratio = 4.41, P < 0.05).

Oncogenic comparison of human papillomavirus type 58 E7 variants.

PMID: 30575267 2019 Journal of cellular and molecular medicine

Figure: Our previous studies showed that the three most common circulating HPV58 E7 strains carry amino acid substitutions (in red font) from HPV58 E7 prototype (in black, bold italic font) as follows: threonine (T) at position 20 to isoleucine (I) and glycine (G) at position 63 to serine (S), or designated as T20I/G63S within Variant 1 (V1); G at position 41 to arginine (R) and G at position 63 to aspartic acid (D), or designated as G41R/G63D within Variant 2 (V2); T at position 74 to alanine (A) and D at position 76 to glutamic acid (E), or designated as T74A/D76E within Variant 3 (V3).

Figure: Single amino acid variation of either T20I (V1A) or

The polymorphisms of LCR, E6, and E7 of HPV-58 isolates in Yunnan, Southwest China.

PMID: 29695285 2018 Virology journal

Abstract: Six non-synonymous amino acid substitutions (including S71F and K93 N in the E6, and T20I, G41R, G63S/D, and V77A in the E7) were affecting multiple putative epitopes for both CD4+ and CD8+ T-cells.

Table: G63S

Discussion: In addition, G63S/D (a positively selected site) affected the MHC class-I binding peptide, and V77A, the most common non-synonymous substitution in the HPV-58 E7, made the predicted MHC class-II binding peptide VRTLQQLLM (E7, 77-85) disappear.

E6 and E7 Gene Polymorphisms in Human Papillomavirus Types-58 and 33 Identified in Southwest China.

PMID: 28141822 2017 PloS one

Result: The positively selected sites for HPV-33 E6 were K35N, K93N, and R145I; for HPV-33 E7 were S29T, A45V, A45E, and Q97L; for HPV-58 E6 were K93N, R145K; and for HPV-58 E7

Discussion: The HPV-58 E6 mutations T20I and G63S have been reported to increase the risk of developing cervical cancer; interestingly, in the present study, we found that these two mutations were positively selected.

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.

PMID: 28794033 2017 Journal of virology

Abstract: A whole-genome sequence signature analysis identified 3 amino acid changes, 16 synonymous nucleotide changes, and a 12-bp insertion strongly associated with the

Result: A genome-wide association analysis using mutual information (MI) examination identified three additional amino acid changes within L2 (N231T and M446L) and L1 (L5F); 16 synonymous nucleotide mutations within E1, NCR2, L2, L1, and the LCR; and a 12-bp insertion within the LCR as being strongly associated with the E7 T20I/G63S variant (Table 2).

Genetic Variability in E6 and E7 Oncogenes from Human Papillomavirus Type 58 in Mexican Women.

PMID: 29945151 2017 Intervirology

Abstract: For E7, 17 known mutations were found, the most frequent were C632T (T20I), 35.30%, G760A (G63S), 35.30%, and t744g 74.50%.

Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.

PMID: 23136059 2013 International journal of cancer

Discussion: Amino acid substitution(s) T20I and/or G63S at E7 is(are) associated with a higher risk for CIN3 and invasive cervical cancer.

Discussion: Isolates carrying G63S and/or T20I were found to have an independent increase in risk for CIN3 and invasive cervical cancer.

Discussion: Only one variant harbored G63S alone without T20I.

Human papillomavirus type 58: the unique role in cervical cancers in East Asia.

PMID: 22571619 2012 Cell & bioscience

Abstract: An HPV58 variant (E7 T20I, G63S) commonly detected in Hong Kong was found to confer a 6.9-fold higher risk of developing

Introduction: The substitution G63S results in a serine which could be phosphorylated by casein kinase II, and a positive association between phosphorylation rate and oncogenic potential of E7 has been reported.

Introduction: This variant harboring two amino acid substitutions, T20I and G63S, in the E7 protein was found to associate with an odds ratio of 10.14 (95% confidence interval = 10.14-74.72) for the development of cervical cancer, which was 6.9-fold higher than HPV58 variants without these sequence variations.

Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women.

PMID: 20870281 2010 Gynecologic oncology

Abstract: CONCLUSIONS: These findings suggest that C632T (T20I) and G760A (G63S) variants in HPV58 E7 are probably risk factors associated with the development of cervical cancer in Chinese women.

Abstract: For HPV58, the presence of C632T (T20I) and G760A (G63S) variants in E7 showed a positive trend of the association with the severity of neoplasia (P(trend)<0.05, chi2 test for trend).

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