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 HPV mutation literature information.


  Human papillomavirus prevalence in invasive anal cancers in the United States before vaccine introduction.
 PMID: 23609590       2013       Journal of lower genital tract disease
Abstract: Among HPV-16-positive cases, 37% were identified as prototype variant Ep, and 63% were nonprototypes: 33% Em, 12% E-G131G, 5% Af1, 4% AA/NA-1, 3% E-C109G, 3% E-G131T, 2% As, and 1% Af2.
Discussion: in anal neoplasia tissue from a mostly HIV positive population, which may support their hypothesis that infection with the E-G131G or E-G131T genotypes pose elevated risk for malignant progression.


  HPV11 mutant virus-like particles elicit immune responses that neutralize virus and delineate a novel neutralizing domain.
 PMID: 10639310       2000       Virology
Abstract: A conformationally dependent epitope for the binding of three neutralizing monoclonal antibodies (mAbs) has been mapped to residues G(131)T(132) of the L1 major capsid protein.
Abstract: The new mAbs are unlike the neutralizing mAbs previously mapped to residues G(131)T(132) in that they bind both prototype and HPV11:G131S mutant VLPs.



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