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 HPV mutation literature information.


  Human papillomavirus prevalence in invasive anal cancers in the United States before vaccine introduction.
 PMID: 23609590       2013       Journal of lower genital tract disease
Abstract: Among HPV-16-positive cases, 37% were identified as prototype variant Ep, and 63% were nonprototypes: 33% Em, 12% E-G131G, 5% Af1, 4% AA/NA-1, 3% E-C109G, 3% E-G131T, 2% As, and 1% Af2.
Method: Subsequently, nucleotide identities at position 109, 131, 132, 143, 145, 178, 350 were determined with a Pyromark Q96 MD (Qiagen, Valencia, CA, USA) to identify the variants AA/NA-1, Af1, Af2, As, E-C109G, E-G131G, E-G350, Em, Ep.
Discussion: in anal neoplasia tissue from a mostly HIV positive population, which may support their hypothesis that infection with the E-G131G or E-G131T genotypes pose elevated risk for malignant progression.


  Human papillomavirus type 16 E2 and E6/E7 variants.
 PMID: 15721413       2005       Gynecologic oncology
Abstract: The frequency distribution of variants in the sample set was 37 European prototypes and 27 E-G350, 16 AA, 5 Af1, 2 Af2, 8 E-C109G, 3 E-G131G, and 2 As.



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