High frequency of HPV16 European variant E350G among Mexican women from Sinaloa.
PMID: 30425223
2018
The Indian journal of medical research
Abstract: It was further observed t
Result: Of these, 23 (74.2%) had a base pair substitution at the E350G position, with this change being the most prevalent.
Discussion: However, the E350G (or L83V) intra-variant primarily found in our study was not associated with the development of CC in all European populations.
Discussion: In addition, functional studies demonstrated that the E350G E6 variant has biological advantages over the E-P (European-Prototype).
Discussion: The higher association of AA and E350G variants and cancer risk may be linked to a better ability to evade the host immune system and/or an increased oncogenic potential associated with intrinsic biological properties of viral proteins.
Human papillomavirus type 16 long control region and E6 variants stratified by cervical disease stage.
PMID: 24823962
2014
Infection, genetics and evolution
Method: Based on an equal distribution of prototype (E350T) and variant (E350G) sequences overall we ascertained that 50 samples from each of the cases and controls would be sufficient to observe a 50% difference in the distribution of the prototype and variant sequences between the cases and controls (p < 0.05).
Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.
Result: However, in women over 45 years, two variants prevail: E350G/442C and Af2 which are present in 35.53% (27/76) and 25% (19/76) respectively, statistical analyses were significant for only HPV16 E and Af variants related to patients' age (p < 0.0001).
Result: Moreover, among women under 45 years, E350G/442C is the most predominant variant with 48.15% of cases (13/27).
Table: E350G
Di
Discussion: In some European populations, HPV16 E350G variant was strongly associated with the oncogenicity and persistency of HPV16 infection.
Discussion: Interestingly, the E113D (A442C) was detected in 37.9% of samples and was exclusively found in the European variant (E350G/442C).
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.
Result: Among the EUR lineage, the variants E350G and E131G were seen in 9.9% (30/304) and 3.0% (9/304) of the 304 women, respectively.
Discussion: In our study, phylogenetic analysis of the E6 gene showed an extremely higher prevalence of the As lineage (49.7%), followed by E-prototype lineage (36.4%), E350G-lineage (9.9%), E131G-lineage (3.0%) and Af-1 variant (4.3%).
Molecular variants of HPV-16 associated with cervical cancer in Indian population.
PMID: 19358280
2009
International journal of cancer
Abstract: Similar distribution of the variants was seen from the different centres/regions, with the European variant E350G being the most prevalent (58%), followed by American Asian variant (11.4%).
An oligoarray for the detection of human papillomavirus type 16 variants.
PMID: 17877642
2007
International journal of gynecological cancer
Abstract: We applied a sensitive and specific stacking hybridization assay using an oligoarray for the detection of Asian-American (AA) and European (E) (E350G) HPV 16 variants.
HPV mutation literature information.
PMID: 
2018
The Indian journal of medical research
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