Result: M1K made epitope affinity increase; R17G, D32N, D32E, I34R, L35V, P66A, H85Y and L90V changed epitope number and affinity; E120D a
Result: In HPV-16 E6, I34R, L35V, R62I, P66A and L90V all located in beta-fold, E120D, D32N, D32E located in the periphery of the spatial protein structure and close to the active region of znic granules.
Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.
Result: A subset of the A2 sublineage appeared to be uniquely defined by the C335T (H85Y) and A442C (E120D) in E6 and A646C (N29H) in E7, and a subset of the A1 sublineage was uniquely defined by the C790T (R77C) in the E7 gene.
Discussion: Additionally, HPV16 E6 H85Y and E120D belong to the A2 sublineage in this study but are not associated with cervical cancer.
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.
Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.
Abstract: The H85Y and E120D variants in E6 were si
HPV mutation literature information.
PMID: 
2022
Virology journal
Browser Board
Co-occurred Entities
Filtrator
ViMRT