literature

HPV mutation literature information.

Genetic variations in E6, E7 and the long control region of human papillomavirus type 16 among patients with cervical lesions in Xinjiang, China.

PMID: 30930693 2019 Cancer cell international

Result: These caused the amino acid to change from threonine to serine (T22S), aspartic acid to asparagine (D25N), aspartic acid to glutamic acid (D25E), aspartic acid to glutamine (D25Q), isoleucine to arginine (I27R), asparagine to aspartic acid (N58D), asparagine to serine (N58S), aspartic acid to glutamic acid (D64E), leucine to valine (L83V), threonine to lysine (T86K), glutamic acid to aspartic acid (E113D), leucine to phenylalanine (L28F), asparagine to histidine (N29H) and asparagine to serine (N29S), respectively.

Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.

PMID: 25889023 2015 Virology journal

Discussion: According to the HPV variants found in this study, the amino acid substitutions circulating in Southern Mexico are: Q3E, R10G, Q14H, D25N, I27L, I27R I27T, L28V, E29K, E29Q, E29G, I52L, K68T, F69L, H78Y, L83V (the most frequent) and E113D.

Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.

PMID: 24150786 2014 Journal of medical virology

Abstract: By Western blot analysis, a similar ability to degrade p53 was observed among EUR E6, As E6, EUR E6-L83V and As E6-E113D.

Analysis of mutations in the E6 oncogene of human papillomavirus 16 in cervical cancer isolates from Moroccan women.

PMID: 23953248 2013 BMC infectious diseases

Result: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C) and Q14D (C143G/G145T) and were observed respectively in 65%, 41.8%, 38.8% and 30.1% of total samples.

Discussion: The most prevalent non-synonymous variants were L83V (T350G), H78Y (C335T), E113D (A442C), Q14D (C143G/G145T) and R10I (

Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China.

PMID: 24099556 2013 BMC cancer

Result: Nucleotide variations of E6 included 4 silent mutations of G94A, G176A, C215T and T241G and 5 missense mutations of A131C, T178G/A, C335T, T350G and A442C, which led to amino acid variations of R10G, Result: The rank orders of E6 variants in amino acid were as follows: D25E (49.7%, 151/304), L83V (9.9%, 30/304), H78Y (4.3%, 13/304), R10G (3.0%, 9/304) and E113D (2.6%, 8/304).

Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.

PMID: 22574185 2012 PloS one

Abstract: Bayesian analysis identified several important amino acid positions that may be driving adaptive selection in the HPV 16 population, including R10G, D25E, L83V, and E113D in the E6 gene.

Discussion: Position E113D mutation was also implied in invasive cervical carcinoma.

Genetic diversity of HPV-16 E6, E7, and L1 genes in women with cervical lesions in Liaoning Province, China.

PMID: 21436703 2011 International journal of gynecological cancer

Abstract: Sequences of the E6 gene revealed 4 amino acid changes of variants D25E and L83V, with 48.3% (69/143) and 11.2% (16/143), respectively, and variants H78Y and E113D in this study.

Human papillomavirus type 16 E6 gene variations in Chinese population.

PMID: 19699050 2010 European journal of surgical oncology

Abstract: The rank orders of incidence of HPV 16 prototype and E6 variants were as follows: D25E (62%), the prototype (17%), E113D (9%), L83V (6%) in case subjects; the prototype (71%), D25E (23%), L83V/E113D (7%) in control subjects.

Analysis of mutations in the E6/E7 oncogenes and L1 gene of human papillomavirus 16 cervical cancer isolates from China.

PMID: 16603519 2006 The Journal of general virology

Abstract: In addition to D25E and E113D, the following E6 variations were found in this study: R129K, E89Q, S138C, H78Y, L83V and F69L.

Abstract: Prevalences of HPV16 E6 D25E and E113D variants were 67.3 and 9 %, respectively.

Human papillomavirus typing of invasive cervical cancers in Italy.

PMID: 17192187 2006 Infectious agents and cancer

Result: Sequence analysis of the E6 gene in 25 HPV 16 positive ICC cases showed the presence of the T350G mutation in the great majority (18/25, 72%), in 4 cases also accompanied by other mutations; among the mutations identified, A257G, C335T, T350G, A442C lead to amino acid changes (I52V, H78Y, L83V, E113D, respectively), while C256T, T286A, A289G are silent not leading to amino acid changes.

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