Result: M1K made epitope affinity increase; R17G, D32N, D32E, I34R, L35V, P66A, H85Y and L90V changed epitope number and affinity; E120D a
Result: In HPV-16 E6, I34R, L35V, R62I, P66A and L90V all located in beta-fold, E120D, D32N, D32E located in the periphery of the spatial protein structure and close to the active region of znic granules.
Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.
Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.
HPV mutation literature information.
PMID: 
2022
Virology journal
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