literature

HPV mutation literature information.

The polymorphism analysis and epitope predicted of Alphapapillomavirus 9 E6 in Sichuan, China.

PMID: 35057815 2022 Virology journal

Result: Calculated by Codeml software using Naive NEB and Bayes Empirical Bayes models, seven positive selection sites of alpha-9 HPV E6 were detected, there were D32E of HPV-16 E6, K35N, K93N, R145I of HPV-33 E6, K93R of HPV-52 E6, K93N, R145K of HPV-58 E6.

Result: In HPV-16 E6, I34R, L35V, R62I, P66A and L90V all located in beta-fold, E120

Prevalence and distribution of human papillomavirus (HPV) in Luoyang city of Henan province during 2015-2021 and the genetic variability of HPV16 and 52.

PMID: 35246180 2022 Virology journal

Abstract: For HPV16, The most prevalent mutations were T266A (27/27) and N181T (7/27) for L1, D32E for E6 and S63F for E7 in HPV16.

Result: The most frequently non-synonymous mutation in HPV E6 genes were T7220G (A) (5/18), which made D32E mutation.

Discussion: Although the D32E mutation in E6 protein did not change the B-cell epitopes, the gene variation altered the other gene profiles.

Association of cervical carcinogenesis risk with HPV16 E6 and E7 variants in the Taizhou area, China.

PMID: 34217247 2021 BMC cancer

Result: The three most prevalent nucleotide substitutions were T178G (D32E) (191/298, 64.1%) in the E6 gene and A647G (N29S) (195/298, 65.4%) and T846C (192/298, 64.4%) in the E7 gene, which are specific to the A4 (Asian) sublineage.

Discussion: It has been reported that the prevalence of both non-synonymous substitutions D32E and N29S

Discussion: Our results showed that the oncogenicity of E6 D32E and E7 N29S variations was associated with the development of cervical cancer.

Genetic variability and functional implication of HPV16 from cervical intraepithelial neoplasia in Shanghai women.

PMID: 31670402 2020 Journal of medical virology

Abstract: Amino acid substitutions (D32N/E, E36Q, H85Y, and E120D in E6 and N29H/S and R77C in E7) were predicted to have an effect on conserved structural and functional residues, and five amino acid substitutions (H85Y, E36Q, I34L, and D32E in E6; R77C in E7) would potentially change the secondary structure.

Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai.

PMID: 31832087 2019 Infectious agents and cancer

Abstract: However, T7220G (D32E) variation in HPV16 E6 and A7689G (N29S) in HPV16 E7 increased the incidence of HSIL compared to the <HSIL group (P = 0.036 and 0.022).

Distribution of human papilloma virus type 16 E6/E7 gene mutation in cervical precancer or cancer: A case control study in Guizhou Province, China.

PMID: 26192265 2016 Journal of medical virology

Abstract: D32E/M28V/L94P mutation was higher in the cervical cancer and precancer compared with the prototype.

Abstract: HPV-16 E6/E7 genetic variations, such as D32E/M28V/L94P, are more prevalent in cervical cancer or precancer than those in the controls.

Abstract: Mutations were simultaneously detected at the E6-D32E (T96A) and E7-M28V (A82G)/L94P (

PMID: 17429529 2007 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: D32E/N29S mutation rate was 38.9% (28/72), the detection rate increased with the severity of cervical lesions (P < 0.05).

Abstract: A mutation, E6-D32E (T96G) coincided with a specific type of E7 mutation, N29S (A86G).

Abstract: CONCLUSION: HPV 16 was the most common type in women with cervical lesions in Beijing, D32E/N29S variant associated with the cervical lesions.

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